Accommodating larger families in a single hotel room is a huge challenge in Manhattan due to the limited space in many hotels. However, some hotels offer suites or interconnected rooms that can comfortably accommodate families of at least five people. Here are some options to consider:

1. The Manhattan at Times Square Hotel:

   • Some room configurations include suites with multiple bedrooms, suitable for families. Family One Bed Suite can sleep up to 6.

   • Located in the heart of Times Square.

2. Courtyard by Marriott New York Manhattan/Herald Square:

   • This hotel offers family-friendly accommodations, including suites with extra space accommodating up to 5.

   • Convenient location near Herald Square and Macy's.

3. Hilton Times Square:

   • The hotel offers suites that can accommodate larger families. Various connection room combinations that can sleep 8.

   • Centrally located in Times Square.

4. Radio City Apartments:

   • While technically an apartment-style accommodation, it's worth considering for larger families - some apartments can accommodate 6.

   • Centrally located near Rockefeller Center.

5. Hotel Beacon:

   • Located on the Upper West Side, Hotel Beacon offers suites with kitchenettes. Family suites can accommodate up to 6.

   • The proximity to Central Park and family-friendly attractions makes it a good choice.

Space in Manhattan everywhere is at a premium, but these hotels provide some suitable options in the City That Never Sleeps